Scientists at the University of Geneva (UNIGE) have identified a mechanism behind chronic bacterial infections in cystic fibrosis, one of the most common genetic diseases in Switzerland. According to the research, the disease impairs the protective barrier of the airways through abnormal activation of a protein called connexin 43, which disrupts cellular organisation and compromises the integrity of the airway lining. The findings suggest that targeting this dysfunction at its source could help limit infections in people with cystic fibrosis.
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